Lyell Immunopharma, Inc.

General Information

We are a preclinical biotech company. We are a T cell reprogramming company dedicated to the mastery of T cells to cure patients with solid tumors. We have assembled a world-class team, comprising some of the foremost scientific leaders in the fields of oncology and adoptive cell therapy (ACT), including Drs. Rick Klausner, Nick Restifo, Stan Riddell and Crystal Mackall.

We are utilizing our proprietary Gen-R and Epi-R technology platforms to develop a multi-modality product pipeline with four IND submissions expected by the end of 2022. Each of our programs provide opportunities to expand into additional indications beyond the patient populations we are initially targeting. Our product candidates are:

*Our lead CAR program, LYL797, is expected to be an IV-administered CAR T cell product candidate targeting ROR1 non-small cell lung cancer and triple-negative breast cancer. (ROR1 is a protein coding gene.) If successful, we anticipate expanding the program to include patients with potentially hormone receptor positive (HR+) breast cancer, ovarian cancer and other solid tumors. We expect to submit an Investigational New Drug (IND) application for LYL797 in the first quarter of 2022.

*We are applying our Epi-R technology to develop our product candidate, LYL845, which is expected to be an IV-administered autologous TIL therapy in multiple solid tumors. If successful, we expect to expand development to potentially include melanoma, cervical cancer, head and neck cancer, pancreatic cancer, breast cancer, colorectal cancer and non-small cell lung cancer. We expect to submit an IND for LYL845 in the second half of 2022.

*Our collaborator, GSK, is developing a New York esophageal squamous cell carcinoma 1 (NY-ESO-1) TCR T cell product candidate, NY-ESO-1c259, currently in pivotal development. We are collaborating with them to potentially enhance this clinical-stage product candidate with Gen-R and Epi-R. Preclinical efforts and IND-enabling studies are under way. We anticipate GSK will conduct initial clinical trials with the enhanced product candidate in synovial sarcoma and multiple other solid tumor indications. We anticipate an IND submission in the first half of 2022.

(Note: Lyell Immunopharma priced its IPO at $17 – the mid-point of its $16-to-$18 range – on 25 million shares, in line with the terms in its prospectus, to raise $425 million.)

Industry: Pharmaceutical Preparations
Employees: 188
Founded: 2018
Contact Information
Address 400 East Jamie Court, Suite 301 South San Francisco, California 94080
Phone Number (650) 695-0677
Web Address
View Prospectus: Lyell Immunopharma, Inc.
Financial Information
Market Cap $4128.11mil
Revenues $8.95 mil (last 12 months)
Net Income $-230.28 mil (last 12 months)
IPO Profile
Symbol LYEL
Exchange NASDAQ
Shares (millions): 25.0
Price range $17.00 - $17.00
Est. $ Volume $425.0 mil
Manager / Joint Managers Goldman Sachs/ BofA Securities/ J.P. Morgan/ Morgan Stanley
CO-Managers -
Expected To Trade: 6/17/2021
Status: Priced
Quiet Period Expiration Date:
Lock-Up Period Expiration Date:
SCOOP Rating
Rating Change