General Information


We are a clinical-stage biopharmaceutical company focused on discovering and developing differentiated therapies for patients with liver and gastrointestinal, or GI, diseases. Our most advanced program targets the farnesoid X receptor, or FXR, which is central to modulating liver and GI diseases. FXR agonism has been investigated in large-scale clinical trials and has shown clinically relevant improvements in non-alcoholic steatohepatitis, or NASH, a liver disease characterized by excess liver fat, inflammation and fibrosis. We believe that potency, sustained exposure and continuous target engagement are key to optimizing therapeutic benefit with an FXR targeted therapy. Leveraging our extensive chemistry and biology expertise, we have built a proprietary library of over 2,500 FXR compounds, and have selected two novel, oral FXR candidates from a unique chemical scaffold, MET409 and MET642, that have the potential to deliver improved tolerability and therapeutic outcomes. MET409 and MET642 were purposefully designed to be differentiated treatments for NASH as potent, sustained FXR agonists, with the ability to be dosed orally once daily. With our program, we believe we can develop differentiated FXR agonist therapies for NASH and other GI diseases.

Employees: 32
Founded: 2014
Contact Information
Address 3985 Sorrento Valley Blvd., Suite C, San Diego, CA 92121, US
Phone Number (858) 369-7800
Web Address
View Prospectus: Metacrine
Financial Information
Market Cap $336.96mil
Revenues $0 mil (last 12 months)
Net Income $-33.3 mil (last 12 months)
IPO Profile
Symbol MTCR
Exchange NASDAQ
Shares (millions): 6.5
Price range $13.00 - $13.00
Est. $ Volume $85.0 mil
Manager / Joint Managers Jefferies/ Evercore/ RBC Capital Markets
CO-Managers Canaccord Genuity
Expected To Trade: 9/16/2020
Status: Priced
Quiet Period Expiration Date:
Lock-Up Period Expiration Date:
SCOOP Rating
Rating Change